Ozempic is a brand name for the medication semaglutide, which belongs to a class of
drugs called glucagon-like peptide-1 receptor agonists (GLP-1 RAs). Ozempic is
primarily used as a treatment for type 2 diabetes but has also been approved for weight
management in some countries. Other medications in this class of GLP-1 agonists
include Wegovy, Saxenda, and Mounjaro.
GLP-1 (glucagon-like peptide-1) is a hormone that plays a role in regulating hunger and
satiety signals in the brain. The GLP-1 agonist medications, therefore, mimic this
hormone that we naturally make,
Ozempic and other GLP-1 agonists (medications within that class) work by achieving the following:
1. GLP-1 Receptor Activation: Ozempic works by binding to and activating GLP-1
receptors found in the pancreas, brain, stomach, and other organs.
2. Glucose Control: By activating GLP-1 receptors in the pancreas, Ozempic
stimulates the release of insulin, a hormone that helps lower blood sugar levels.
3. Brain Signaling: GLP-1 receptors in the brain regulate hunger and satiety signals.
By stimulating these receptors, Ozempic can influence the brain’s perception of
hunger and help control food cravings.
4.. Delayed Stomach Emptying: GLP-1 receptor agonists like Ozempic slow down the
rate at which the stomach empties its contents into the small intestine. This
effect helps to increase feelings of fullness, reduce appetite, and can lead to
decreased food intake and subsequent weight loss.
5. Reduced Glucagon Release: Ozempic also suppresses the release of glucagon
from the pancreas, a hormone that raises blood sugar levels. By reducing
glucagon production, Ozempic helps prevent excessive glucose production by
the liver, further contributing to improved blood sugar control.
It is important to note that these medications should be used as prescribed by a
healthcare professional and in conjunction with a healthy diet and regular exercise to
maximize their effectiveness. If you have specific questions or concerns, it is advisable
to consult with Dr. Korman who can provide personalized information based on your medical
history and condition.
The amount of weight loss you can expect while taking Ozempic or other GLP-1
receptor agonists can vary from person to person. Weight loss results depend on
various factors, including individual characteristics, adherence to a healthy diet, regular
exercise, and overall lifestyle habits.
Clinical trials of GLP-1 receptor agonists have shown that they can lead to weight loss in
people with type 2 diabetes or without diabetes who are using them for weight
Results can vary from person to person. To achieve the best weight loss results, it is recommended to use GLP-1 receptor agonists as part of a comprehensive weight loss plan that includes a healthy and balanced diet, regular physical activity, and lifestyle modifications. Working closely with a healthcare professional, such as a doctor or registered dietitian, can provide personalized guidance and help you set realistic weight loss goals based on your