Compounded GLP-1 Supplements: Cheaper Alternatives, or Pure Snake Oil?

As the FDA cracks down on compounded formulas of weight loss drugs such as Wegovy (semaglutide) and Zepbound (tirzepatide),  Americans are turning to unregulated “GLP-1” dietary supplements that claim to “supercharge” the body’s GLP-1 levels to accelerate weight loss.

Sold as gummies, powders, patches, and capsules, these products are cheaper, over-the-counter alternatives.

Although these supplements aren’t a recent medical breakthrough, they are getting a lot of attention from experts. Pharmacology professor Jamie Alan of Michigan State University referred to them as “rebranded, older weight-loss products” with no scientific proof that they mimic prescription GLP-1 drugs.

What’s the difference between GLP-1 medications and GLP-1 supplements?

Prescription GLP-1 medications directly activate receptors that control appetite and blood sugar. They require monitoring from a licensed medical professional. 

Over the counter GLP-1 supplements use ingredients such as ashwagandha, green tea extract, berberine, chromium, and saffron. These ingredients have minimal or inconsistent evidence for weight loss, and may even have harmful long-term effects. Supplements are not regulated or tested by the FDA before they reach consumers, so there are high risks of interactions for those with medical conditions or taking other medications.

Why the GLP-1 Supplement Popularity?

Because of the shortage of GLP-1 prescription drugs, the FDA allowed compounding pharmacies to make copycat versions of Wegovy and Zepbound that were much cheaper- $129 per month versus the brand name price that went upwards of $1,300. Now that the shortages are over, compound pharmacies must stop production. With only the expensive name brand GLP-1s such as Wegovy and Zepbound, supplement companies have an opportunity to enter the market. 

These affordable options are an easy sell to consumers. However some retailers such as Walmart have been urged to remove these products from their shelves. 

Although food can slightly influence GLP-1 activity through high fiber and healthy-fat diets, supplements are unable to match the metabolic effect of these medications. 

For more information on medical weight loss, contact Dr. Korman’s office today:

310-577-5540